Whether you’re looking for a sprawling warehouse or a heavy-duty data center, flexible office space or multi-modal harbor access, the Greater St. Louis area offers a wide range of competitively priced real estate options.
Search for available sites and buildings in the St. Louis region
Commercial and Industrial
Commercial real estate and industrial space in the St. Louis region are not just affordable, they’re less expensive than competing markets, including in the Midwest. According to year end 2025 data from CoStar, 4- and 5-star office space averages $29.65, 38% lower than the U.S. market average of $47.94 PSF. And industrial space leases at $7.46 per square foot, about 39% less than the U.S. market average of $12.14 PSF.
As the 19th largest U.S. office market, the St. Louis metro offers 145 million square feet of space with an 10.4% vacancy rate. The 19th largest warehousing market in the country, the region gives businesses a variety of options amid 345 million square feet of industrial warehouse space with a 5.0% vacancy rate. Much of this space is located near business centers and major transportation and intermodal hubs, making travel and the distribution of goods and people fast and efficient.
As the largest office center in the region, Downtown St. Louis offers over 28 million square feet of office space. Similarly, other large concentrations of office space located near key highway intersections, including the St. Louis County seat of Clayton, provide businesses with numerous choices for their ideal location and budget.
Distribution Sites
St. Louis’ major public ports, America’s Central Port in Illinois and the Municipal River Terminal in the City of St. Louis, offer a variety of available sites with access to the Mississippi River, railways, and highways. America’s Central Port is a 1,200-acre intermodal, mixed-use business and industrial park adjacent to the Mississippi River and located in a foreign trade zone. The North Riverfront Commerce Corridor, which includes the Municipal River Terminal, is a 3,000-acre multimodal logistics and business district in the City of St. Louis.
St. Louis Lambert International Airport, MidAmerica St. Louis Airport in Illinois and other regional airports have available development sites with direct runway access near interstate highways. Leasable buildings and hundreds of acres of land are available close by, all with highway access and locations in foreign trade zones. Within the region, businesses have a wide variety of options for distribution sites and buildings strategically located near intersections of the interstate and regional highway network. Distribution parks with modern bulk buildings are also available in numerous locations.
Manufacturing Areas
Greater St. Louis is a major manufacturing center with industrial zoning throughout the 15-county region. Buildings are available in almost any size and with access to heavy utilities, highways, rail connections, and other key manufacturing requirements.
Land
The St. Louis region offers a wide range of available sites of all sizes, including greenfield and shovel-ready locations. These sites provide options for direct access to all modes of transportation as well as office and industrial centers.